The growing pains of ifosfamide

Growing Pains

CONTEXT The term growing pains describes a common, benign syndrome of recurrent discomfort that occurs in young children. First described in the 1800s, the etiology of this condition remains unclear. The peak incidence does not correspond to a time of rapid growth. Children typically report bilateral pain in the lower extremities that occurs late in the day or at night. EVIDENCE ACQUISITION T...

Growing pains.

Growing pains.

Background: MeCP2, methyl-CpG-binding protein 2, binds to methylated cytosines at CpG dinucleotides, as well as to unmethylated DNA, and affects chromatin condensation. MECP2 mutations in females lead to Rett syndrome, a neurological disorder characterized by developmental stagnation and regression, loss of purposeful hand movements and speech, stereotypic hand movements, deceleration of brain ...

Growing pains in children

Growing pains are the most common form of recurrent musculoskeletal pains in childhood and are present in 10-20% of children, mainly between the ages of 3-12 years. The diagnosis is based on typical historical clinical characteristics with a normal physical examination. The etiology is still unknown but current theories include low pain thresholds, as in fibromyalgia and local overuse pain that...

Growing pains: practitioners' dilemma.

NEED AND PURPOSE OF REVIEW Though cases of 'growing pains' are quite common in pediatric practice, very little attention has been given to it, even in the standard text books. The resultant confusion among practitioners regarding diagnosis and management of this condition needs to be addressed. METHODS USED FOR LOCATING, SELECTING, EXTRACTING AND SYNTHESIZING DATA PubMed search was performed ...